Download Advances in Immunopharmacology. Proceeding of the Fourth by J. W. Hadden (Eds.) PDF
By J. W. Hadden (Eds.)
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Extra info for Advances in Immunopharmacology. Proceeding of the Fourth International Conference on Immunopharmacology, Osaka, Japan, 16–19 May 1988
The subacute toxicity studies via the intravenous route which was proposed for human application have been performed using animals, in which rats were given γinterferon at a dosage of 10^ or 10^ U/kg per day for 4 weeks and monkeys received a dosage of 10^ or 10^ U/kg per day for 4 weeks, respectively. Drugrelated changes were not at all found in rats, because the interferon have minimal cross-species activity, and the neutralizing antibody against γinterferon was detected in all the rats during the study.
T h u s , we f e e l t h a t o n e way i n w h i c h b i d i r e c t i o n a l c o m m u n i c a t i o n t a k e s p l a c e b e t w e e n t h e immune a n d n e u r o e n d o c r i n e s y s t e m s i s v i a s i g n a l m o l e c u l e s and r e c e p t o r s w h i c h a r e common t o c e l l s of b o t h s y s t e m s . PRO-OPIOMELANOCORTIN (POMC) PRODUCTION BY LEUKOCYTES S t i m u l a t e d l y m p h o c y t e s p r o d u c e m o l e c u l e s t h a t a r e v e r y s i m i l a r , if not i d e n t i c a l , to the p e p t i d e hormones: c o r t i c o t r o p i n ( A C T H ) , e n d o r p h i n ( E N D ) , t h y r o t r o p i n ( T S H ) , human c h o r i o n i c Gonadotropin ( h C G ) , p r o l a c t i n ( P R L ) , a n d p o s s i b l y o t h e r s (Table 1 ) .
The list of substances that might influence the immune response is presented in Table 1. ) ypothalamic hormones somatostatin Corticotrophin Releasing hormone Neuroactive peptides Substance Ρ Neurotensin VIP Cholecystokinin Enkephalins Hormones Corticosteroids Insulin VrsfoSin°""°"^° Vasopressin aSrhorn^ones Oxytocin ACTH TSH Prolactin Growth hormone Endorphins Others Prostaglandins Histamine Bradykinin Bombesin Products of immune cells Interleukins TSH Thymosins VIP Lymphokines (MIP, CSP) Histamine Interferons Serotonin ACTH Prostaglandins )9-Endorphin Others ?