Download Advances in Understanding Kingella kingae by Joseph W. St. Geme III PDF

By Joseph W. St. Geme III

This publication describes the transforming into physique of data at the epidemiology, medical manifestations, transmission, pathogenesis, analysis, and therapy of Kingella kingae infectionsin youngsters. furthermore, it covers experimental equipment which have been built to review the microbiology, genetics, and virulence elements of K. kingae, info that gives the basis for brand new methods to remedy and prevention of K. kingae disease. With this content material in brain, excerpts from the publication can be of relevance for clinicians who take care of pediatric sufferers, for scientific microbiologists who're fascinated by detecting organisms in scientific specimens, and for scientists who're learning K. kingae in an attempt to strengthen novel pursuits for antimicrobial treatment and new ways to prevention.

First remoted within the Nineteen Sixties via Elizabeth O. King, a bacteriologist on the CDC, Kingella kingae used to be principally overlooked over the subsequent twenty years as a human pathogen due to its unusual restoration from sufferers with affliction. even though, lately K. kingae has been more and more famous as a clinically very important pathogen in young ones, and is at present famous because the top reason behind osteoarticular infections in childrens in more and more international locations. study into this organism has grown enormously during the last 15 years, leading to a greater appreciation of the significance of K. kingae in pediatric sufferers and of the molecular mechanisms of ailment.

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Porsch and Katherine A. Rempe Colonization The pathogenesis of Kingella kingae disease is believed to begin with colonization of the oropharynx. In order to colonize this site, the organism must adhere to respiratory epithelial cells. Early studies demonstrated that K. kingae expresses hair-like surface fibers and suggested that these fibers may be type IV pili, in particular given that they react with antibodies raised against Kingella denitrificans type IV pili. Kehl-fie et al. [1] confirmed that the K.

Arch Dis Child 100(8):742–747. 1136/archdischild2014-307490 17. Basmaci R, Bonacorsi S, Ilharreborde B, Doit C, Lorrot M, Kahil M, Visseaux B, Houhou N, Bidet P (2015) High respiratory virus oropharyngeal carriage rate during Kingella kingae osteoarticular infections in children. Future Microbiol 10(1):9–14. 117 18. Basmaci R, Ilharreborde B, Doit C, Presedo A, Lorrot M, Alison M, Mazda K, Bidet P, Bonacorsi S (2013) Two atypical cases of Kingella kingae invasive infection with concomitant human rhinovirus infection.

Rempe K. kingae can cause uncomplicated bacteremia or can disseminate from the bloodstream to joints, bones, or the endocardium [50, 51]. Analysis of a collection of K. kingae systemic isolates showed that strains recovered from the blood of patients with uncomplicated bacteremia were generally piliated but typically expressed relatively few pili [52]. In contrast, strains recovered from joint fluid samples, bone aspirates, or the blood of patients with endocarditis were generally non-piliated [52].

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