Download Advances in Virus Research, Vol. 62 by Karl Maramorosch, Frederick A. Murphy, Aaron J. Shatkin PDF
By Karl Maramorosch, Frederick A. Murphy, Aaron J. Shatkin
The Advances in Virus examine sequence covers a various variety of in-depth stories delivering a worthwhile assessment of the present box of virology. This eclectic quantity includes six experiences overlaying subject matters when it comes to plant viruses, evolution of viruses with hosts and mobilephone acceptance via viruses. Six entire studies on: * Varicella Virus - Mononuclear cellphone interplay * Evolution of mobile acceptance via Viruses: A resource of organic Novelty with scientific Implications * Infectious Pancreatic Necrosis Virus: Biology, Pathogenesis and Diagnostic tools * buildings of Picrona-like plant viruses: Implications and functions * Cucumoviruses * Co-Evolution of Viruses with Hosts and Vectors and attainable Paleontology
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Extra resources for Advances in Virus Research, Vol. 62
EVOLUTION OF CELL RECOGNITION BY VIRUSES 27 Each replication-competent component of a quasispecies distribution can, in principle, initiate a virus diversification process to generate a spectrum of genotypes and phenotypes. RNA replicons constitute a highly dynamic ‘‘RNA world’’ in a relatively more static [but only relatively! (Bushman, 2002)] DNA-based biosphere of differentiated organisms, as noted two decades ago by Holland and colleagues (1982). The central objective of this review is to examine the effect of virus variation on cell recognition and some of its biological consequences.
1996; Yuan and Shih, 2000). 26 ERIC BARANOWSKI ET AL. , 2003). Within-host variation is the first step in the process of long-term diversification of viruses in successions of transmission events from infected to susceptible hosts. Comparison of consensus nucleotide sequences of independent isolates of the same virus originated from a single source of infection allows a calculation of the rate of evolution. As expected from the complex quasispecies dynamics, rates of evolution for RNA viruses are not constant with time (a ‘‘clock’’ does not operate) and are often in the range of 10À2 to 10À4 substitutions per nucleotide and year.
By participating in the first step of virus infection, receptors divert from their usual activity in cellular metabolism and provide yet another example of molecular parasitism, essential in the life cycle of viruses. It has not been possible to predict the type of receptors likely to be used by a virus from its phylogenetic position, nor from its biological properties. The diversity of receptors is reciprocated by their unforeseeable exploitation by viruses, independently of their genome structure and replication strategy.