Download Biomaterials for Cardiac Regeneration by Erik J. Suuronen, Marc Ruel PDF

By Erik J. Suuronen, Marc Ruel

This e-book deals readers a finished biomaterials-based method of reaching clinically profitable, functionally built-in vasculogenesis and myogenesis within the middle. insurance is multidisciplinary, together with the position of extracellular matrices in cardiac improvement, whole-heart tissue engineering, imaging the mechanisms and results of biomaterial-based cardiac regeneration, and autologous bioengineered middle valves. Bringing present wisdom jointly right into a unmarried quantity, this booklet offers a compendium to scholars and new researchers within the box and constitutes a platform to permit for destiny advancements and collaborative methods in biomaterials-based regenerative drugs, even past cardiac applications.

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1995; Bowers et al. 2010). There is also a significant change in myocardial stiffness from late gestational age to the neonatal period (Jacot et al. 2010; Gershlak et al. 2013). Mature myocytes express only α3β1 integrin and selectively adhere to Laminin and Collagen IV (Terracio et al. 1991; Borg et al. 1984), the major components of their basement membrane. Heart valves must undergo further remodeling and maturation after birth in response to large changes in transvalvular pressure (Aldous et al.

2009; Chung et al. 2007). Alignment can also promote differentiation and maturation of cardiac progenitor cells (Domian et al. 2009). Cardiomyocytes cultured on polyacrylamide gels that match the stiffness of the native myocardium exhibit better sarcomere alignment and generate stronger traction forces compared to cells on softer or stiffer substrates (Jacot et al. 2008). The beating frequency of cardiomyocytes is also affected by extracellular stiffness: “healthy” myocardial stiffness promotes beating while stiffer “scar-like” stiffness inhibits beating (Engler et al.

1991; Borg et al. 1984), the major components of their basement membrane. Heart valves must undergo further remodeling and maturation after birth in response to large changes in transvalvular pressure (Aldous et al. 2010). The endocardial cushions remodel into elongated, stress-resistant valve leaflets during late gestation and in the postnatal period (Kruithof et al. 2007). Collagen distribution becomes highly compartmentalized (Peacock et al. 2008). Although the exact structure, composition, and mechanical properties differ for each of the four valves, the ECM tends to become highly organized and stratified into distinct layers: the fibrosa (primarily collagen), the spongiosa (GAGs and PGs), and the ventricularis/atrialis (elastin-rich) (Combs and Yutzey 2009; Wiltz et al.

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