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By Hans-Otto Georgii

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17 Type II collagen is the main building block of the fibril with type XI forming a core around which the type II collagen molecules are deposited. Two alternative splice forms of type II collagen are known. Type IIa contains all exons and is present in early embryonic structures such as somites and notochord. Type IIb, from which exon 2 has been removed, is secreted by cartilaginous tissues. The function of type XI appears to be similar to that of type V, which forms a core for type I fibrils in other tissues.

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Maturation-related changes in proteoglycans of fetal articular cartilage. Arch Biochem Biophys 1981; 208:535-547. 26. Buckwalter JA, Kuettner KE, Thonar EJ-MA. Age-related changes in articular cartilage proteoglycans: Electron microscopic studies. J Orthop Res 1985; 3:251-257. 27. Brandt KD, Fife RS. Aging in relation to the pathogenesis of osteoarthritis. Clin Rheum Dis 1986; 12:117-130. 28. Hardingham T, Bayliss M. Proteoglycans of articular cartilage: Changes in aging and in joint disease. Sem Arthritis Rheum 1990; 20:12-33.

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