Download Cell Therapy for Lung Disease by Julia Polak PDF

By Julia Polak

Using stem cells to assist with lung regeneration and service is a singular remedy which may aid part out the necessity for traditional surgical or pharmacological methods at present hired to regard ailments of the lung or different organs. the current ebook explores all avenues of this new kind of remedy, relocating rapidly, yet intensive, from the elemental technological know-how of lung improvement, to the analyses of alternative stem phone forms to be had for regeneration and directly to the appliance of this data base in preliminary scientific trials. during this quantity a stellar crew of researchers converge, from various angles, to aid in the direction of clarifying the fundamental mechanisms of lung fix. those variety from uncomplicated options of regeneration and lung improvement, the analyses of quite a few telephone forms that could be fascinated by lung fix, to methods of constructing complicated lung buildings, together with synthetic and bioartificial lungs. The e-book deals an perception into fix mechanisms of the diseased lung, the position of particular lung niches and gives details on preliminary scientific trials in addition to using stem cells as autos for gene remedy. inventive technological facets of assessing stem phone engraftment of stem mobile bioprocessing also are incorporated during this quantity.

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Transbronchial biopsies provide longitudinal evidence for epithelial chimerism in children following sex mismatched lung transplantation. Thorax 60(1), 602 (2005). qxd 2/12/2010 5:14 PM Page 33 Current Knowledge of Stem Cell Therapy 33 80. , and Lohrs, U. Cellular chimerism of the lung after transplantation. An interphase cytogenetic study. Am J Clin Pathol 115(4), 525–533 (2001). 81. W. Bone marrow stem cells do not repopulate the healthy upper respiratory tract. Pediatr Pulmonol 34(4), 251–256 (2002).

32. M. Mesenchymal stem cells as vectors for lung disease. Proc Am Thorac Soc 5(6), 711–716 (2008). 33. , and Driscoll, B. Stem/progenitor cells in lung development, injury repair, and regeneration. Proc Am Thorac Soc 5(6), 703–706 (2008). 34. L. Lung epithelial progenitor cells: lessons from development. Proc Am Thorac Soc 5(6), 675–681 (2008). 35. E. The differentiation of distal lung epithelium from embryonic stem cells. Curr Protoc Stem Cell Biol, Chapter 1, Unit 1G 1 (2007). 36. H. Evidence for stem-cell niches in the tracheal epithelium.

7. Clinical Trials in Lung Cell Therapy While a relatively large number of clinical trials in cell therapy approaches have occurred in other disciplines, for example cardiovascular diseases, only a small number of trials have been initiated for pulmonary diseases. qxd 2/12/2010 5:14 PM Page 25 Current Knowledge of Stem Cell Therapy 25 progenitor cells might have therapeutic effects in lung. Nonetheless, given the overall safety record of the cardiovascular trials as well as the safety and efficacy record of recent trials evaluating systemic MSC administration to patients with either graft vs host disease or with Crohn’s disease, there is more enthusiasm to push ahead with clinical trials in pulmonary diseases.

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