Download Chikungunya Virus: Advances in Biology, Pathogenesis, and by Chioma M. Okeoma PDF
By Chioma M. Okeoma
This e-book describes the molecular biology, pathogenesis, epidemiology, and capability ideas for keep watch over of chikungunya virus (CHIKV) an infection. It bargains perception into the constitution and capabilities of CHIKV proteins as they relate to host reaction, interplay with the arthropod vector, and vaccination. a close account of either the epidemiological outlook and the medical syndrome of CHIKV an infection is supplied. The advanced host-virus interplay and the signaling pathways that mediate such interactions also are lined. in the course of the ebook, images and charts are used to supply stimulating dialogue on vital findings within the box of chikungunyalogy. The chapters are written with a world viewpoint by means of specialists of CHIKV from all over the world. This venture is principally major provided that CHIKV is a pathogen of globally public wellbeing and fitness difficulty. even if the presence of CHIKV an infection isn't really worldwide but, around the globe dissemination is anticipated sooner or later due mostly to the shortcoming of powerful treatment/therapy, effective regulate of transmission, and information approximately mechanisms of pathogenesis. also, globalization of CHIKV is based on its mode of dissemination (mosquito vector) and move border go back and forth and migration.
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Extra resources for Chikungunya Virus: Advances in Biology, Pathogenesis, and Treatment
2009; Rudd et al. 2012; Schilte et al. 2012; Teng et al. 2012). The role of type I IFN in CHIKV pathogenesis has been further investigated in human cells and mouse models. Although the MAVS (also known as Cardif or IPS1) pathway contributes to the immune response both in cell culture of human fibroblasts and in mice, evidence for a MyD88-dependent sensor in preventing viral dissemination was demonstrated only in mice. It has been shown that interferon type I receptor (IFNAR) expression is required in nonhematopoietic cells but not in hematopoietic cells, as IFNAR−/− → WT bone marrow chimeras are able to clear the infection, whereas WT → IFNAR−/− chimeras succumb to disease.
Médecine et Maladies Infectieuses 42:93–101 Rinaldo CR Jr, Overall JC Jr, Glasgow LA (1975) Viral replication and interferon production in fetal and adult ovine leukocytes and spleen cells. Infect Immun 12:1070–1077 Robin S, Ramful D, Le Seach F, Jaffar-Bandjee MC, Rigou G, Alessandri JL (2008) Neurologic manifestations of pediatric chikungunya infection. J Child Neurol 23:1028–1035 Robinson MC (1955) An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. Clinical features.
2004). An estimated 50,000 cases occurred in this outbreak with little awareness outside the area. Later, in 2006, CHIKV was identified as the causative agent in a number of febrile illness cases in Cameroon. The virus sequence obtained from this cluster revealed a high degree of homology with the strains from the Republic of Congo in 2000 suggesting continuous circulation of this lineage over at least 6 years in central Africa (Peyrefitte et al. 2007). Only about 400 cases of illness were reported during this outbreak, however, a follow-up cross-sectional serosurvey suggested that the recent infection rate was over 50 % (Demanou et al.