Download Cilia and Mucus: From Development to Respiratory Defense by Matthias Salathe PDF
By Matthias Salathe
This ebook info advances in study relating to cilia, mucus, and mucociliary clearance, reading alterations in mucus expression and goblet mobile metaplasia, and assessing the facility of the mucociliary method to answer abnormalities. acknowledges that cilia and dynein fingers play pivotal roles in constructing mammalian embryos!Examines the function of genetics in common and irregular ciliary function!Discussing medical basics, present diagnostic concepts, and clinically validated remedies, Cilia and Mucus analyzes the law of ciliary waves on the mobile point considers irregularities of higher and reduce airlines and cilia in structures of the physique explores power modulators of airway mucin secretion proposes a singular treatment for airway hypersecretion because of the epidermal development issue cascade clarifies gamma digital camera imaging to degree mucociliary clearance describes the impression of purinergic receptors and dry powder mannitol on airway passages and extra! With contributions from over a hundred foreign researchers and clinicians, and containing over 1300 references, drawings, photos, tables, and equations, Cilia and Mucus is a special single-source reference for pulmonologists, physiologists, immunologists, allergists, otolaryngologists, pediatricians, microbiologists, easy scientists, and graduate and clinical institution scholars in those disciplines.
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Extra resources for Cilia and Mucus: From Development to Respiratory Defense
Keeping the beat: form meets function in the Chlamydomonas flagellum. Bioessays 17:847–854, 1995. 2. RE Stevens. Ciliogenesis in sea urchin embryos—a subroutine in the program of development. Bioessays 17:331–340, 1995. 3. LA Perkins, EM Hedgecock, JN Thomson, JG Culotti. Mutant sensory cilia in the nematode Caenorhabditis elegans. Dev Biol 117:456–487, 1986. 4. KA Johnson, JL Rosenbaum. Polarity of flagellar assembly in Chlamydomonas. J Cell Biol 19:1605–1611, 1992. 5. KG Kozminski, KA Johnson, P Forscher, JL Rosenbaum.
Mutant sensory cilia in the nematode Caenorhabditis elegans. Dev Biol 117:456–487, 1986. 4. KA Johnson, JL Rosenbaum. Polarity of flagellar assembly in Chlamydomonas. J Cell Biol 19:1605–1611, 1992. 5. KG Kozminski, KA Johnson, P Forscher, JL Rosenbaum. A motility in the eukaryotic flagellum unrelated to flagellar beating. Proc Natl Acad Sci USA 90:5519–5523, 1993. 6. JL Rosenbaum, DG Cole, DR Diener. Intraflagellar transport: the eyes have it. J Cell Biol 144(3):385–388, 1999. 7. RL Morris, JM Scholey.
CONCLUSIONS Our data argue that kinesin-II drives the transport of IFT rafts in the anterograde direction from the neuronal cell body, out along the dendrite, to its final destination at the tip of the sensory cilium. Then, CHE-3 cytoplasmic dynein retrieves both the anterograde motor, kinesin-II, and its associated IFT raft cargo from the ciliary tip back to the transition zone to replenish the available pools of anterograde motor and raft particles. The fact that kinesin-II, OSM-1, and OSM-6 all accumulate at the transition zone suggests that this region serves as a ‘‘loading dock’’ for IFT rafts and the specific cargo that they may be carrying.