Download Clinical management of chronic obstructive pulmonary disease by Thomas Similowski, William Whitelaw, Jean-Philippe Derenne PDF

By Thomas Similowski, William Whitelaw, Jean-Philippe Derenne

This reference offers a entire evaluate of the latest ideas used to evaluate, deal with, and deal with sufferers in every one part of persistent obstructive pulmonary sickness (COPD)-offering the newest diagnostic modalities to spot and distinguish parts of COPD in past, extra reversible stages.

Contains views from the realm future health association at the epidemiology and keep an eye on of COPD in Africa, South the US, and japanese Europe!

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Sample text

Changes in the pressure-volume curve can occur quite early in the evolution of COPD, before declines in FEV 1 occur or before there is obvious emphysema on conventional chest radiographs. Pressure-volume indices correlate with anatomic evidence of emphysema at surgery (29) or postmortem (30) and with findings on high resolution CT (31). Although the concept of high compliance in COPD is well established, it is The Lung in Transition from Health to Disease 7 important to recall that patients with obstructive lung disease are an inhomogeneous population and that a variety of changes in the pressure-volume relationship of the lung is seen in smokers (32).

However, because of the much more rapid rate of decline of lung function in AAT-COPD than in usual COPD, studies in AATCOPD may prove useful in developing proof of concept of drugs for usual COPD. Although a number of efforts have been made in the past to develop synthetic anti-neutrophil elastases as drugs, none were successful. Anti-metalloprotease drugs are currently under study. The hope is that enhanced understanding of the inflammatory process in the lungs of those with COPD will lead to the development of new classes of drugs that are tailor-made to the disease.

The term chronic bronchitis was first recorded in the early 19th century. In 1819, Laennec published illustrations and descriptions of emphysema using lung specimens inflated with air and dried in the sun as the basis of his observations. In the second edition of his book, he extended and synthesized his observations on pathology and clinical manifestations, including descriptions of auscultatory findings using the stethoscope that he had invented. Laennec noted the persistent overinflation of the emphysematous lung and its decreased elastic properties.

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