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By Peter G. Kopelman, Michael J. Stock

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Recruit SMCs, Primary Care Physicians (PCP)s, and subjects for the study. 3. Pilot test the feasibility of all major elements of the SMC intervention including data collection and self-management consultant protocols and activities with a small number of subjects. 4. Implement the intervention in both the Detroit Department of Health and the University of Michigan Department of Family Medicine. 5. Conduct a randomized clinical trial to evaluate the relative effectiveness of the SMC intervention compared to usual care in improving blood glucose control and diabetes-related quality of life.

Compare effects of diabetes selfmanagement education on health outcomes in different ethnic groups. 4. Explore changes in medical treatment, such as medications, reported in studies that result from diabetes self- management education. 5. Explore cost savings of diabetes selfmanagement. 6. Identify gaps in the in the research on the effects of components of diabetes education on health outcomes. Meta-analytic procedures will be used to synthesize both published and unpublished research reports.

The Idd3 locus has been mapped to a 780 kb region of chromosome 3. The most likely candidate gene in this region is the IL-2 gene. This gene Studies 35 shows several structural differences between alleles that are derived from resistant or susceptible strains of mice. However, definitive evidence for or against a role of IL-2 has not yet been obtained, since it has not been possible until recently to target genes in the NOD genetic background. In this study we will establish gene knock-in technology on the NOD genetic background by using NOD/129 F1 ES (embryonic stem) cells, which we have recently found to be very effective in all the steps of gene targeting.

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