Download Clinical Vignettes for the USMLE Step 2: PreTest by McGraw-Hill Education PDF
By McGraw-Hill Education
Now up to date to mirror the USMLE Step 2 examination, with larger emphasis on case shows and diagnostic talents. nearly four hundred new medical vignettes with accompanying questions (500 questions in all)--now that includes increased solutions referenced to best textbooks or magazine articles. Reviewed via McGraw-Hill's clinical pupil Advisory Committee to make sure simulation of the USMLE test-taking event.
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Additional resources for Clinical Vignettes for the USMLE Step 2: PreTest Self-Assessment & Review
Some tail fibers even have enzymatic activity, allowing for both penetration of the cell wall and the formation of pores in the cell membrane. Real World HIV must bind to a receptor called CCR5 on white blood cells in order to infect them. Some people lack this receptor and are thus immune to HIV. There was recently a case in which an HIV-positive man with leukemia received a bone marrow transplant from a donor that lacked CCR5. Not only was his leukemia cured, but this transplant also resulted in remission of his HIV infection because the white blood cells from his newly acquired bone marrow were not susceptible to HIV infection.
Real World The antibiotic penicillin targets the enzyme that catalyzes the cross-linking of peptidoglycan. If a gram-positive cell cannot cross-link its cell wall, it no longer serves as an effective barrier. The bacterium becomes susceptible to osmotic damage and lyses. Most bacteria have developed resistance mechanisms to penicillin, although a few bacteria—including Streptococcus pyogenes, which causes strep throat and some skin infections, and Treponema pallidum, which causes syphilis—are still very sensitive to this antibiotic.
DNA viruses must go to the nucleus in order to be transcribed to mRNA. The mRNA then goes to the cytoplasm, where it is translated to proteins. Genetic material from positive-sense RNA viruses stays in the cytoplasm, where it is directly translated to protein by host cell ribosomes. Negative-sense RNA viruses require synthesis of a complementary RNA strand via RNA replicase, which can then be translated to form proteins. DNA formed through reverse transcription in retroviruses also travels to the nucleus, where it can be integrated into the host genome.