Download Subcellular Basis of Contractile Failure: Proceedings of the by Craig T. January, Harry A. Fozzard (auth.), Borivoj Korecky, PDF

By Craig T. January, Harry A. Fozzard (auth.), Borivoj Korecky, Naranjan S. Dhalla (eds.)

This monograph includes 20 chosen papers provided on the Symposium on Subcellular foundation of Contractile Failure which used to be held in Ottawa in the course of may perhaps 11-13, 1989 and is designed for the convenience ofthose who have been not able to wait this occasion. it truly is now more and more turning into transparent that quite a lot of calcium is in detail focused on the pathogenesis of a large choice of center ailments. therefore, the investigations about the function of calcium chan­ nels and their regulatory mechanisms in center functionality in addition to of the intra­ mobile calcium overload in cardiac disorder are offered right here. seeing that sodium can also be thought of to persuade the cardiac contractile strength by means of chang­ 2 ing the intracellular focus of calcium throughout the Na +-Ca+ trade 2 mechanism within the telephone membrane, the position of Na +-Ca+ alternate in center func­ tion in addition to pathology of contractile failure is mentioned. In view of the recent­ ly came across implications of the oxygen unfastened radicals in mobile damage, papers in regards to the function of those radicals in middle sickness are incorporated during this publication. For the aim of readability, diverse chapters were prepared lower than 3 major headings: (I) function of cations in center functionality, (II) Cardiac hypertrophy and cardiomyopathies, and (III) Ischemic middle ailment and cardiac failure.

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Additional info for Subcellular Basis of Contractile Failure: Proceedings of the Symposium Sponsored by the Council of Cardiac Metabolism, International Society and Federation of Cardiology and International Society for Heart Research, May 11–13, 1989, Ottawa, Canada

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Glucagon's chronotropic action is calcium dependent. J. Pharmacol. Exp. Ther. 241:833-837, 1987. 30. MacLeod, K. , Rodgers, R. L. and McNeill, J. H. Characterization of glucagon-induced changes in rate, contractility and cyclic AMP levels in isolated cardiac preparations of the rat and guinea pig. J. Pharmacol. Exp. Ther. 217:798-804, 1981. 31. , Hofmann, F. and Trautwein, W. Modulation of Ca current during the phosphorylation cycle in the guinea pig heart. Pflligers Arch. 407:123-128, 1986. 32.

405:285-293, 1985. Fischmeister, R. and Hartzell, H. C. Mechanism of action of acetylcholine on calcium current in single cells from frog ventricle. J. Physiol. Lond. 376:183-202, 1986. George, W. , Polson, J. , O'Toole, A. G. and Goldberg, N. Elevation of 3' ,5'-cyclic monophosphate in rat heart after perfusion with acetylcholine. Proc. Natl. Acad. Sci. USA 66:398-403, 1970. Flitney, F. W. and Singh, J. Evidence that cyclic GMP may regulate cyclic AMP metabolism in the isolated frog ventricle.

Species variability and apparent disparities between changes in beating, adenylate cyclase activation, and cyclic AMP concentration. J. Clin. Inv. 57:551-558, 1976. 29. , Zaloga, G. , Willey, S. , Clapper, M. and Holaday, J. W. Glucagon's chronotropic action is calcium dependent. J. Pharmacol. Exp. Ther. 241:833-837, 1987. 30. MacLeod, K. , Rodgers, R. L. and McNeill, J. H. Characterization of glucagon-induced changes in rate, contractility and cyclic AMP levels in isolated cardiac preparations of the rat and guinea pig.

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